Radu Socoteanu
Institute of the Romanian Academy, Romania
Title: Eco-friendly features in long-chain studies for pharmaceutical tetrapyrrolic formulation targeting efficient drug delivery
Biography
Biography: Radu Socoteanu
Abstract
Porphyrinic compounds represent the main class of tetrapyrrolic structures which play an important role in photodiagnosis and photodynamic therapy of malignant tumors. Therefore, the synthesis, investigation spectral properties and in vitro evaluation at the cellular level of such structures are of current interest in medicinal chemistry. Despite the complete absence of toxicity related to the porphyrinic compounds themselves, almost all stages involving classical synthesis and most of the analytical evaluation stages involve high toxicity. Unconventional microwave synthesis proved to be in this case the main factor in reducing the number of side products and toxic solvents usually used in the classical obtaining process for acethoxy and methoxy periphery A3B porphyrin type structures. Also, the evaluation by AFM microscopy of important features, such as aggregation capacity or interaction with other structures involved in pharmaceutical formulation (e.g. polyethylene glycol or several nanoparticles) prove to be an efficient eco-friendly tool for evaluation of such nano-systems.