Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 9th World Congress on Green Chemistry and Technology Amsterdam, Netherlands | Hyatt Place Amsterdam Airport | Rijnlanderweg 800, 2132 NN Hoofddorp .

Day 2 :

Conference Series Euro Green Chemistry-2018 International Conference Keynote Speaker Claudia Crestini photo
Biography:

Claudia Crestini is associate professor at the University of Rome Tor Vergata. Director of the Laboratory of Polyphenols Chemistry & Materials Science, her work is internationnally recognized as a leading contribution to Green Chemistry using natural polyphenols. It is focused on the development of new methods of structural analysis of polyphenolic polymers, development of new materials and products by chemical/biotechnological modification and development of innovative stimuli responsive nanomaterials from natural polyphenols. She has published more than 140 publications on international refereed journals and over 150 contributions to international conferences and invited presentations. H-index 41, citations > 5000 (source google scholar).

 

Abstract:

Tannins are natural polyphenols found in most higher plants around the globe. They play a significant role in defending the plant against insects, infections, fungi or bacteria; this role stems from their capability to form complexes with proteins, polysaccharides and metals, and hence provide protection to the vulnerable parts of the plants against invasive microbial extracellular enzymes. However, their exploitation as renewable high added value products is to date not extensive despite their interesting intrinsic properties, including high biocompatibility and biodegradability. The fundamental positive health effects of tannins, which are connected to their high antioxidant activity and their role as radical scavengers, allow for protection from diseases associate with the presence of free radicals in the body, such as cancer, arthritis, and degenerative eye and neurological disorders, and display significant potential for biofilm control undoubtedly revealing intriguing potential for their application in biomedical fields that is yet to be explored. In this frame our research group, aiming at designing a rational process for tannins valorization developed an innovative 31P NMR analytical technique for fast and reliable quantification of all the different phenolic groups present in complex tannns matrices and applied it to the selective functionalization of tannins of different origins and structures in order to tune biological and chemico physical properties such as hydrophobicity and chelation. Furthermore, the high tendency to supramolecular interactions was succesfully exploited for the design and development of nanostructures for synergistic controlled drug delivery by ultrasonication.

 

Conference Series Euro Green Chemistry-2018 International Conference Keynote Speaker Dimitris S. Argyropoulos photo
Biography:

Dimitris Argyropoulos, Professor of Chemistry at North Carolina State University, is internationally recognized for his leading contributions to Green Chemistry using wood biopolymers. His work focuses at promoting our understanding of the structure and reactivity of lignin and the development novel NMR and material science techniques for the structural elucidation and the upgrading of these biopolymers representing otherwise unsolved, intractable problems in lignin based material’s chemistry. The efforts of his research group have been disseminated in excess of 200 scientific papers, numerous scientific conferences and invited presentations.

 

Abstract:

Carbon fibers represent a class of materials with enormous potential for many material and other engineering applications for our society. There are projections that by 2020 the actual demand for carbon fibers will be such that the traditional poly-acrylonotrile precursors used today will not be enough to address the projected demand. Consequently, it is imperative that new precursors based on the foundations of Green Chemistry need be developed. In this respect technical lignins present us with formidable challenges but also with enormous opportunities and they are to  be explored in detail during this presentation.   In our earlier effort we have embarked in describing and discussing the importance of propargylation chemistry on lignin so as to synthesize lignin macromonomers for thermal polymerization via Claisen rearrangement 1, 2. We have also discussed that the molecular weight and glass transition temperatures of the thermally polymerized lignin improves significantly relative to the starting material. The intricate polymer structure created within lignin as a result of the benzopyran double bond thermal polymerization chemistry is offering a regular covalently linked framework from which, after carbonization, a regular carbon fiber material could. As such, thermally polymerized propargylated softwood lignin emerges as a prospective material for the synthesis of bio-based Carbon Fiber precursor. Various reactivity considerations that are to be discussed in the presentation 3 were addressed by a series of experiments where initially Acetone Soluble Kraft Lignin (ASKL) was propargylated, thus occupying all readily accessible and highly reactive phenolic–OHs, followed by methylation of the remaining phenolic OH’s to limit phenoxy radical induced thermal polymerization. All the polymerization reactions were conducted by heating the samples at 180 °C for three hours and the corresponding molecular weights and distributions were determined.

As anticipated, the installation of the propargyl groups in more reactive positions, more readily prone to Claisen rearrangement and thermal polymerization events, offered much better developed molecular weights able to offer Carbon Fibers.

 

  • Green Chemistry and Technology | Green Chemical Engineering | Environmental Chemistry and Pollu􀆟 on Control | Green Analytical Chemistry
Location: Meeting Place 2
Speaker

Chair

Dimitris S. Argyropoulos

North Carolina State University, USA

Speaker

Co-Chair

Ricardo Reis Soares

Federal University of Uberlandia, Brazil

Session Introduction

Ricardo Reis Soares

Federal University of Uberlandia, Brazil

Title: Fatty acids, olefins and green diesel from catalytic edible oils hydrolysis

Time : 11:40- 12:10

Speaker
Biography:

Prof. Ricardo Soares has completed his PhD in 1997 at UFRJ/Brazil and postdoctoral studies from Oklahoma University and University of Wisconsin, USA. He is the coordinator of the Biofuels Graduate Program at Federal University of Uberlandia, Brazil. He has published more than 25 papers in reputed journals and has been working with several brazilian industries, such as PETROBRAS and CBMM.       

Abstract:

Studies using heterogeneous catalysts for the hydrolysis reaction of edible oils still are in early stage. Recently, it was found that the aqueous solution of glycerol, formed after the hydrolysis, may suffer the reaction of aqueous phase reform (APR) producing H2 and CO2. The H2 can be used in the hydrogenation of unsaturated free fatty acids formed, allowing to obtain a specific fatty acid of higher added value. The present work demonstrates that you can tune in the final product by choosing the appropriate sequential catalyst system as shown in the figure below.

 
 

ZHANG Feng

Chinese Academy of Inspection and Quarantine, China

Title: Green Analytical Techniques in Food Analysis

Time : 12:10-12:40

Speaker
Biography:

Prof. Dr. Feng ZHANG, was born in 1974 in Shandong province, China, Director of the Institute of Food Safety in Chinese Academy of Inspection and Quarantine, Professor of Xi'an Jiaotong University, the winner of funding of Max-Planck Society. Prof. Dr. Feng ZHANG returned to China in 2006 and focused his attention on the application of chromatography/mass spectrometry in food and drug analysis, measurement and standard material development and other fields. Dr. ZHANG has published more than 100 papers in peer-reviewed journals and 6 books, authorized 9 patents and established 6 national standards. In the recent years, as the project leader, he has undertaken more than 30 research projects and has obtained many research awards from government and national research association.

 

Abstract:

The development of greener analytical techniques is a topic of great interest. There is an increasing need for new analytical methods that can be used for assuring safety and quality in food samples, including adulterants, pesticide residues and unknown functional components. Ultra performance convergence chromatography (UPC2) is considered a valuable tool helping to separate and determine compounds differing by subtle structural differences. UPC2 presents several advantages over high performance liquid chromatography (HPLC), it takes less column equilibration time and consumes less organic reagents. UPC2 has recently been successfully used to separate and determine a lot of analytes, including many pharmaceutical compounds.

In this work, recent applications of UPC2 for the analysis of different compounds in food and biological samples were reviewed, in the hope of helping chromatography users to have a new look on the possibilities offered by this technique. Furthermore, a simple, highly sensitive and fast analytical method based on UPC2 with photo-diode array detection (PDA) has been developed to quantify quantify sulfonamides, monosaccharide, and structural analogues of isoflavones isomer in food. Additionally, authentication technology based on fragment markers and high resolution mass spectrometry was developed for the quality assurance and pesticide residues compounds analysis in food.

 

Speaker
Biography:

ANET REŽEK JAMBRAK, Associate professor is working at the Faculty of Food Technology and Biotechnology of the University of Zagreb, Croatia. She is working in the area of nonthermal and advanced thermal processing techniques, food chemistry, food physics, and process engineering. She also has strong international collaboration with renowned scientists. In the period from 2007. Anet Režek Jambrak has published over 80 significant scientific papers, published in top scientific journals with high impact factors (citation more than 1300, h-index 20). She is the winner of the 2016. Young Scientist Award from the International Union of Food Science and Technology.

 

Abstract:

The use of "green" solvents is driven by trends that are focused on finding solutions that minimize the use of solvents or find alternatives. Using the above mentioned solvents is directed towards intensifying the process of extraction and cost-effective production of high-quality extracts. The focus of the study was to use natural and bio-derived solvents in applications. Our goal was to develop, implement and promote the implementation of safer, greener technologies and sustainable industrial solvents. The focus was to select best solvents among water and bio solvent (polar, non-polar, protic and aprotic), including terpene, vegetable oil, MeTHF, NADES (natural eutectic solvent) and Switchable Solvents (Variable solvent) to extract bioactive compounds from sage (S. officinalis). Model predictive tools (Hansen, COSMO-RS) was used to predict the properties and behaviour of the interaction of solvent-solute, and to predict the most favourable performance of these solvents for targeted compounds. The extractions of 1g of sample in 50mL of solvents (water and ethanol) were achieved by high voltage electrical discharge device (IMP-SSPG-1200, Impel group, Zagreb, Croatia). Extraction were made using range of voltage from 15kV-25kV, at 100Hz frequency, during 3 and 9 min treatment time, using Argon as working gas. In this study bioactive compounds (α-thujone and camphor) from sage (S. officinalis) were chosen for COSMO-RS and HANSEN calculations for the selection of green solvents for high voltage electrical discharge-plasma extractions. The best solvents for extraction predicted by COSMO-RS are ethanol, ethylacetat, methylacetat, CPME, DMC, MeTHF.

 

Speaker
Biography:

Weiguo Cheng has completed his PhD from Dalian University of Technology in 2005. He has been professor of chemical engineering at Institute of Process Engineering, Chinese Academy of Sciences since 2014. He is the Member of Committee of Integration of IT Application and Industrialization. He has published more than 50 papers in reputed journals and and 19 invention patents granted including 1 PCT patent.

 

Abstract:

Ethylene glycol (EG) as one of bulk chemicals and dimethyl carbonate(DMC) as environmental friendly chemical material have strategic significance for the basic industries and new industries. The development of green process engineering for coproduction of EG and DMC is highly required as the conventional routes involve either high energy consumption or toxic material. The successful industrial ionic liquid-based green process engineering has several advantages. First, the supported ionic liquid based on synergistic catalytic effect in a fixed bed avoids energy consumption and the loss of catalyst, compared with traditional processes in which the separation of ethylene carbonate and catalyst cost a lot of energy. Second, reactive distillation breaks the equilibrium of the transesterification reaction and converts all ethylene carbonate, thereby improving conversion. This is more straightforward than using a series of fixed bed reactors and ethylene carbonate hydration reactor. Third, energy consumption is reduced (20% ~ 30%) due to the heat integration system compared with traditional process of the coproduction of propylene glycol and dimethyl carbonate. Finally, CO2 released from the upstream of ethylene oxidation plant is utilized in the new process, a big advantage from an ecological point of view, compared with traditional process of the hydration of ethylene oxide. This green chemical engineering technology has been pushed to commercialization. A 33,000 t/a industrial plant is now successfully operating. Because of its economic cost and environmental benign, the new process is believed to be a competitive technology for producing ethylene glycol and dimethyl carbonate.

 

Speaker
Biography:

Morteza Ziyaadini Avarani has completed his PhD at the age of 31 years from University of Sistan & Balouchestan. He is a scientist who works at Chabahar Maritime University. The field of his research interest is the Marine Sciences and Marine Chemistry. He has published more than 15 papers in reputed journals.

Abstract:

The analysis of Chlorophenols (CPs) from environmental samples is an important topic because of their effects on the estrogen's health of humans and wildlife. Sediments or solids are good adsorbents of phenolic pollutants due to their active and extensive adsorbent and superficial surface activity. Sediments can accumulate this material with high concentrations and affect aquatic life. Due to the importance of monitoring the analysis of phenolic compounds in sediment and solid samples, it has been widely studied. Especially in this study, a quick, simple and inexpensive method is used to measure CPs in marine sediments. The reverse phase liquid-liquid microextraction (RP-DLLME) method was used to pre-concentrate of CPs after initial extraction by extraction of ultrasound waves measured by HPLC apparatus. Factors such as extraction time, pH, time and speed of centrifugation, type and volume of extraction solvent and Effect of the volume of disperser solvent were optimized. Under optimal conditions linear ranges for 2-chlorophenol and 2-4-dichlorophenol were between 0.001-2 mg.Kg-1, and 0.2-2 mg.Kg-1 respectively. The concentration factor of 101 and 102 and the relative standard deviation (n=5) 5.9, 3.3 were obtained for 2-chlorophenol and 2,4-dichlorophenol, respectively. Then suggested method has been used for determination of CPs and 0.21-2.18 mg.Kg-1 as well as 0.68-2.55 mg.Kg-1 values were determined for 2-chlorophenol and 2-4-dichlorophenol respectively in marine sediments of Chabahar Bay.

 

Biography:

Prof. Ibrahim Salem is a former Acting president and Vice president for post-graduates & research affairs of Tanta University, Egypt. He is the professor of Physical Chemistry at the Chemistry Department, Faculty of Science, Tanta, Egypt and he published 42 international publications in highly reputed journals. His main research interest is the study of the kinetics of environmental catalytic processes.

 

Abstract:

The kinetics of the homogeneous and heterogeneous catalytic oxidation of three azo dyes in presence of copper ions / copper ions – supported zinc oxide was investigated in aqueous solutions. These dyes were Chromotrope 2B (C2B), Chromotrope 2R (C2R) and Chrysophenen (CRY). The reaction progress was followed by monitoring the decrease in absorbance at ℷmax equals to 512, 511 and 401 nm respectively. The rate of reaction increased with increasing either the concentration of the dye and the catalyst, giving a plateau at high concentrations. On the other hand, the rate of reaction increased gradually with increasing hydrogen peroxide concentration attaining a maximum then decreased thenafter. The reaction rate was also increased with increasing pH and temperature and was found to be entropy controlled.

 

Speaker
Biography:

Dr. Arvind Kumar did PhD in Chemistry at Kurukshetra University, India currently serves as Principal Scientist & Head, Salt and Marine Chemicals Division at CSIR-Central Salt & Marine Chemicals Institute Bhavnagar, Gujarat. His research interests cover design and development of ionic liquids and their use in green chemistry for sustainable technology. He visted Germany under a DAAD Fellowship-2004-05, and USA, under a CSIR-Raman Research Fellowship 2011-12 and is recipient members of the CSIR Rural Technology Award-2008. He has published over 100 research papers, holds several patents, book chapters and articles in popular magazines.          

Abstract:

Room temperature ionic liquids (RTILs) are the organic analogues of inorganic molten salts with melting temperature < 100oC.[1] Being ionic in nature, these compounds are versatile in terms of solvent properties such as low volatility, high thermal stability, wide liquid range and good solvating ability. In view of flexibility of choice of cations or anions, RTILs can designed as low viscosity media suitable for self-assembling of amphiphile molecules or also can also be designed as surfactants by incorporating amphiphilic character in either cation or anion or in both the constituents. Therefore, with extraordinary properties it has been possible to include RTILs as media or as a surfactant or both for construction of colloidal formulations/self-assembled structures. Such structures are highly thermally stable and can be used as templates for many applications such as nanoreactors for preparation of shape/size controlled nanomaterials/quantum dots and their hybrid materials for applications such as novel light harvesting materials with enhanced quantum efficiency. The presentation will focus on construction of a novel all ionic liquid based microemulsion system, its characteristics and application for materials preparation in a recyclic manner. 

 

Mariana Costa

Instituto Politécnico do Cávado e do Ave – IPCA, Campus do IPCA, Portugal

Title: Development of novel autoreactive and ecological monocomponent adhesives
Biography:

Abstract:

The growing concern about environmental issues has become a pressing issue for businesses as the applicable legislation requires more control of any type of hazard that puts human health or the environment at risk. Currently, chemicals are an important aspect of risk assessment and monitoring because of their importance as constituents of the raw materials and their effects on human health and / or the environment.

The aim of this project is developed a microencapsulation device, with reduced content of COVs and reduced risk for Health and Environment. In this work, we report a microfluidic approach, to fabricate monodisperse isocyanate microcapsules with lipophilic cores and polyurethane shells. These microcapsules are generated in a microcapillary microfluidic device we designed using monodisperse O/W emulsion, with high potential application in aeronautic and automobile industries.

The proposed method has advantages of being readily controlled, cost-effective and easy to operate, together with its ability to produce a uniform size. In addition, microfluidics can control the process of encapsulation by varying flow parameters and/or using a proper geometry of microfluidic channels. By microencapsulating the reactive agent, the product is safer for handling by the industry operators, and the activation mechanism can be controlled more precisely (enabling higher flexibility of application / use case scenarios).

The advances made of the current study can be an important contribution in the innovation and development of new methods and products sustainable/green that can, in the future, compete in the market.

 

Fares D Alsewailem

King Abdulaziz City for Science and Technology, Saudi Arabia

Title: Date pits: efficient fillers for polymers
Biography:

Abstract:

Date pit, a byproduct of the palm trees (Phoenix dactylifera L.) with a less value, was successfully used as efficient and eco-friendly filler and reinforcement for polymeric materials. Polystyrene (PS) was used as a matrix to host date pits granules. PS pellets were melt compounded with proper amount of date pit granules using extrusion technique. Morphological and mechanical properties of the prepared composites were investigated to explore effect of date pit particle size on the properties of the composites. It was found that mechanical properties represented by Izod impact strength may be significantly enhanced by controlling date pit particle size (in the range of 0.25-1.00 mm). One potential application of this product is thermal insulation sheets in buildings.  

 

Shilpa Sudhakar Harak

M.S.Gosavi College of Pharmaceutical Education & Research, India

Title: Indian Aloe as an aid for storage of fresh fruits and vegetables
Speaker
Biography:

Dr.Shilpa Sudhakar Harak is a doctrate in Pharmaceutical Chemistry from the Savitribai Phule Pune University. She is a keen academician and researcher. Till recent times, her research was focused on synthetic chemistry for which she has 5 patents published under Indian Patent Act and five research papers in reputed journals. She has now ventured in the field of green alternatives in supporting the cause for environment protection.      
 

 

Abstract:

Hydrocarbons which are used in refrigiration units have been banned and instead their cousins the hydrochlorofluoro carbons are being used highly and still pose a danger to the depleting ozone layer. The ozone layer protects the earth from certain harmful ultra-violet radiations. However for several major reasons, refrigeration has no alternatives, viz. storage of fresh foods like fruits and vegetables.

Aloe vera (indian aloe) was found, identified and collected. The translucent properties of aloe vera indicated that applying a layer of aloe vera gel to the surface of the fresh fruits and vegetables restored the freshness for long time periods (upto 60 days) and prevented microbial growth during the storage period. Microbial studies of these samples done periodocaly indicated growth rate of microbes to be minimal. (no perishing) Also moisture studies have acertained the minimal loss of moisture in comparison to the storage at room temperature and refrigiration. Also physical analysis for skin colour, texture and eruption showed results comparable to refrigerated products. Developing this on a large scale will enable us to reduce the cold storage units employed for storage of fresh fruits and vegetables all over the world. This would reduce the amount of HCFCs being released in the stratosphere and thus benfit mother EARTH and her children.

 

 

Speaker
Biography:

Dr B. O. Ogunsile has completed his PhD at the age of 37 years from University of Ibadan, Nigeria and a Visiting Researcher at Universidad PontificiaBolivariana (UPB), Colombia and Indian Institute of Technology Roorkee(IITR), India. He is Associate Professor (Industrial/Material Chemistry) at the Department of Chemistry, University of Ibadan. His area of interest includes pulping potentiality of non woods, biosorption and remediation of dyes and metals, natural fiber reinforce composites and  nanoscale particles and materials. He has published more than 34 papers in reputed journals and has been serving as a post-graduate science board member at the University of Ibadan, Nigeria. 

Abstract:

High costs and toxicological hazards associated with the physico-chemical methods of producing nanoparticles have limited their wide spread use in clinical and biomedical applications. An ethically sound alternative is the utilization of plant bioresources as a low cost and eco –friendly biological approach. Silver nanoparticles (AgNPs) were synthesized from aqueous leaf extract of Tithonia diversifolia plant. The UV-Vis Spectrophotometer was used to monitor the formation of the AgNPs at different time intervals and different ratios of plant extract to AgNO3 solution. The biosynthesized AgNPs were characterized by FTIR, X-ray Difraction (XRD) and Scanning Electron Microscope (SEM). Antimicrobial activities of the AgNPs were investigated against ten human pathogens using agar well diffusion method. The AgNPs yields were modelled using a second-order factorial design. The result showed that the rate of formation of the AgNPs increased with respect to time while the optimum ratio of plant extract to AgNO3 solution was 1:1. The hydroxyl group was strongly involved in the bioreduction of the silver salt as indicated by the FTIR spectra.  The synthesized AgNPs were crystalline in nature, with a uniformly distributed network of web-like structure. The factorial model predicted the nanoparticles yields with minimal errors. The nanoparticles were active against all the tested pathogens and thus have great potentials as anti-mibrobial agents.

 

Biography:

Radu Socoteanu – senior researcher in the Molecular Structure Department of the Physical Chemistry Institute of the Romanian Academy, Bucharest - is specialized in medicinal chemistry (Ph.D. thesis “Structure, properties and application of some porphyrinic compounds”), in the field of tetrapyrrolic type compounds unconventional synthesis, related analytical and physical chemistry - various techniques from optical spectroscopy to NMR. He has over 35 ISI articles, 8 patents, 2 book chapters; director, partner co-director or member in 22 national and international projects (NATO, MNT-Era-Net, MEC-MCT, CNCSIS).

 

Abstract:

Porphyrinic compounds represent the main class of tetrapyrrolic structures which play an important role in photodiagnosis and photodynamic therapy of malignant tumors. Therefore, the synthesis, investigation spectral properties and in vitro evaluation at the cellular level of such structures are of current interest in medicinal chemistry. Despite the complete absence of toxicity related to the porphyrinic compounds themselves, almost all stages involving classical synthesis and most of the analytical evaluation stages involve high toxicity. Unconventional microwave synthesis proved to be in this case the main factor in reducing the number of side products and toxic solvents usually used in the classical obtaining process for acethoxy and methoxy periphery A3B porphyrin type structures. Also, the evaluation by AFM microscopy of important features, such as aggregation capacity or interaction with other structures involved in pharmaceutical formulation (e.g. polyethylene glycol or several nanoparticles) prove to be an efficient eco-friendly tool for evaluation of such nano-systems.

 

Biography:

 

 

Abstract:

The synthesis of covalent bonds for the formation of amides and esters is of great importance to produce pharmaceuticals, peptides, polymers, etc, these reactions often require a long time  and hard conditions. A wide variety of condensing reagents is known such as acyl azides, uronium salts and carbodiimides can occur these reaction in a short time and at room temperature.

In the last decade, 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride (DMTMM) has been demonstrated to be a very efficient condensing reagent and its use is rapidly increasing due to its high activity, high solubility in water and alcoholic solvents. New alternative condensing agents are of great interest for fine chemistry synthesis to reduce costs and improve yelds.

This in mind, we developed a protocol for the in situ preparation of a library of 4-(4,6-dialkoxy-1,3,5-triazin-2-yl)-4-alkyl-ammonium halides to be used as condensing agents for the formation of amide bonds. Our preliminary results show that these quaternary ammonium salts formulated in situ, further simplify the use of these reagents, reducing their cost. Moreover, in some cases the preformed quaternary ammonium salt is unstable and decomposes quickly while the in situ formulation gives an active and efficient condensing agent. Conversions of over 80% are achieved in most cases in around 15 min.

These activating agents have been efficiently employed for the synthesis of amides and the stabilization of collagen.

 

Speaker
Biography:

 

 

Abstract:

A practical method is designated for the one-pot, multicomponent synthesis of 1,4- dihydropyridine derivatives by cyclo-condensation of aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexanedione, acetoacetanilide and ammonium acetate. Using ethanol as solvent and V2O5/ZrO2 as heterogeneous catalyst, ten novel 1,4-dihydropyridines were synthesized at room temperature (Reaction time<20 min).XRD, TEM, SEM and BET analysis were used to characterize the catalyst materials. Simple work-up, green solvent, short reaction times, moderate reaction conditions and excellent yields (90–96%) are the attractive features of this novel approach. With no need of chromatographic separation, the reaction product is easily separable in pure form.

 

Dominik Lichte

Ruhr Universität Bochum, Germany

Title: Decarboxylative Amination Of Benzoic Acids
Speaker
Biography:

The development of efficient methods for the synthesis of substituted anilines with absolute regiocontrol is a central theme in organic synthesis. In that regard, we were particularly interested in developing a general procedure for C-N bond formation[1-2] via the arylation of weakly acidic amines with benzoic acids. In line with the palladium/copper co-catalyzed decarboxylative coupling rationale developed in the Goossen group[3-4], we now report silver-free conditions under which primary and secondary aliphatic amines as well as diversely substituted anilines can undergo selective mono-arylation with benzoic acids in good to excellent yields (Scheme 1).

Scheme 1 Arylation of aliphatic and aromatic amines via Pd/Cu co-catalyzed oxidative decarboxylative coupling.

This poster will focus on the significant aspects of the reaction development. Decisive for an efficient C-N bond formation is the selection of an apposite oxidant/solvent system. Strikingly, many primary aliphatic amines and also a few secondary acyclic amines can undergo N-arylation following this procedure. An example of a short synthesis of a complex substituted arylamine will be presented in which the C-N bond formation via decarboxylative coupling is an early key step in the overall process to illustrate the applicability of this process. We expect that this methodology will provide new concepts upon which the development of more environmentally friendly oxidative decarboxylative couplings can build for the future.

 


     
 

 

Abstract:

Speaker
Biography:

Abstract:

Fluorine-containing molecules are abundant in pharmaceuticals, agrochemicals and material sciences.[1] In this context, lots of attention has been given to the SCF3 group, which induces higher lipophilicity and membrane permeability to functionalised molecules.[2] Despite their importance and applicability, the synthesis of these molecules through traditional pathways is usually based on waste-intensive and multistep syntheses. The Sandmeyer reaction is one of the few processes using substoichiometric amounts of copper to achieve high yields.[3] However, for pharmaceutical applications, it is desirable to avoid the use of heavy metals. We developed a greener approach for the synthesis of trifluoromethyl thioethers starting from arenediazonium salts in which no heavy metal mediators are needed. Moreover, the reaction is completed within short times and mild conditions. Many substrates are tolerated achieving moderate to good yields. The mechanism was investigated through cyclic voltammetry studies, which highlighted a SET process from the Me4NSCF3 to the arenediazonium salt. Overall, this approach demonstrates that it is possible to perform trifluoromethylthiolation of arene electrophiles in the absence of heavy metal mediators, showing a good applicability for processes in which even ppm quantities of metals need to be avoided.

Speaker
Biography:

Abstract:

Cashew nutshell liquid (CNSL) is an inedible waste product (1.000.000t/a) in the cashew nut processing and is an excellent candidate for the synthesis of bio-based synthetically valuable compounds, as its production does not compete with the land use for food production.[1,2] CNSL is a mixture of phenols bearing a 15-carbon side chain with different degrees of unsaturation.[3,4] We have developed an eco-friendly and waste minimised concept for the synthesis of amine-based surfactants from CNSL. The key step of the procedure is a reductive amination of CNSL with molecular hydrogen in water as solvent, and palladium on charcoal as catalyst. The resulting cyclohexyl amines are successfully converted into N-oxide, betaine and quaternary ammonium tensides. Their surfactant properties (surface tension and critical micellar concentration) have been determined and resulted comparable with those of state-of the-art commercial tensides, opening up a wealth of commercial applications. In the case of the particularly valuable N-oxide surfactant, a one pot synthesis with a remarkably low E-factor of 2 was realised in water as the sole solvent, with a hydrogen peroxide oxidation and purification by simple water extraction, thus avoiding the use of waste-intensive purification techniques. Overall, the process provides a new, eco-friendly procedure for the transformation of renewable waste products into industrially valuable compounds.

Speaker
Biography:

Abstract:

In the presence of catalytic [Ru(p-cym)Cl2]2 and using  Li3PO4 as the base, benzoic acids react with olefins in water to afford the corresponding 2-alkylbenzoic acids in moderate to excellent yields. This C–H alkylation process is generally applicable to diversely substituted electron-rich and electron-deficient benzoic acids, along with a,b-unsaturated olefins including unprotected acrylic acid. The widely available carboxylate directing group can be removed tracelessly or utilized for further derivatization. Mechanistic investigations revealed that the transformation proceeds via a ruthenacycle intermediate.

 

Speaker
Biography:

Abstract:

A [Ru(p-cymene)Cl2]2 catalyst activates allyl alcohols and ethers for the regioselective ortho-C–H allylation of aromatic and heteroaromatic carboxylates. The reaction is orthogonal to most C–H functionalizations with allyl alcohols in that allyl arenes rather than carbonyl compounds are obtained. A wide range of substrates are thus smoothly transformed to allylarenes at 50 °C in phosphate-buffered 2,2,2-trichloroethanol. The reaction concept combines the use of abundant reagents and directing groups in a sustainable, waste-minimized method for C–C bond formation.

Speaker
Biography:

Dr.Amara Dar has completed her PhD in Feb.2018from Institute of Chemistry, University of the Punjab Lahore. Earlier she has done MS (Analytical Chemistry) and BSc.(hons) Chemistry from the same Institution. She has served Center for Undergraduate Studies, University of the Punjab as Lecturer from 2007 till Feb.2018 and at present working as assistant professor. She has published 19 reserach papers in well reputed impact factor journals. She is author of a monograph and a book.

 

Abstract:

Chromium is potential human carcinogen is major component of various industrial effluents. Removal of chromium using various methods has been reported in the literature. Using adsorption technique chromium in the form of chromate was removed in the present study. In countries like Pakistan resources are limited and a cost effective and environmentally benign method is needed to facilitate the community. In order to reduce the effect of chromium pollution novel adsorbents with remarkable adsorption capacities were practiced during this study. Acid treated arjun nuts, beerri ptta capsule and multani mitti along with untreated amberlite IRA 410 were employed for the batch-wise removal of chromate ions from water. In depth mechanism was explored by applying various isothermal model and adsorption capacity (mg/g) of amberlite and acid treated arjun nuts revealed their remarkable potential for chromate adsorption. Time dependence and temperature effect was also studied by applying kinetics and thermodynamics model.

 

Biography:

Malika Mokhtari has completed her Doctorate from Andhra University and postdoctoral studies from University of Tlemcen in Algeria. She is the head a research laboratory since 2009. She has published more than 15 papers in reputed journals and has been serving as revewer.

Abstract:

The catalyst NHZr was synthesized using natural hematite and chloride of zirconium oxide. NHZr was characterized by FT-IR, BET and DRX. This catalyst was applied to photocatalyse 2,4,6-trichlophenol  under UV254 nm irradiation. Effect of different parameters such as pH, catalyst concentration, pollutant concentration were studied. The results showed that 96% of 2,4,6-trichlorophenol was degraded in 180 min of treatment with optimum operating conditions of 0.5 g/L of photocatalyst,  pH medium and 10 mg/L 2,4,6-trichlorophenol. COD elimination and hydrogen peroxide formation were also investigated. Kinetic results showed that photocatalytic reaction obeyed pseudo-first-order .

The NHZr was manufactured by products available, easy to handle, effective on recalcitrant products and has a recyclable character, which gives great value to this photocatalyst.

 

Biography:

Lili Zhen obtained her Master's degree  in  Textile Chemistry, Dyeing & Finishing Engineering  from the National Key Laboratory of  Eco-Textile of the Jiangnan University in China in 2016, with an experimental thesis entitled ‘Thermoplastic modification research of rice straw through graft copolymerization with PEG’. Prior to this, in 2013, Lili Zhen obtained her Bachelor's degree from Jiangnan University working on Light Chemistry Engineering. In 2016, Lili Zhen was chosen as a PhD student within the H2020 program BIOCLEAN under the supervision of Prof. C. Crestini at the University of Roma 'Tor Vergata', Italy.

Abstract:

Tannins are a major source of polyphenolic components after lignin, with 160 000 tons potentially biosynthesized each year. Due to their excellent protein complexing abilitity,tannins have different metabolic and biological roles, such as cell wall construction, against worms, fungi, bacterials and UV protection, that made tannins perfect natrual biofilm control agents in human daliylife life. Tannins posess multiple structure units featured on aromatic oligmer or macromolecular with free phenolic groups and usually classified into hydrolysable tannins that consist of esters of gallic acid with a core sugar, and condensed tannins that are oligomers or polymers of flavan-3-ol units.

The aim of our work has focused on the tayloring of hydrophobic/hydrophilic properties of different tannins. A general chemical process for specific tannin functionalization has been developed and a library of specifically functionalized tannins carrying additional functional groups in specific loading factors has been created. More specifically ammonium groups, carboxylic groups and PEG have been succesfully linked to an array of five different tannins possessing different chemical structures.The products were fully characterized by quatitative 31P NMR, 1H NMR, HSQC, MALDI.

 

Biography:

Abstract:

The MS/MS fragmentation pathway of the cinnamic esters additives was illustrated. There were four analytes (butyl heptanoate, ethyl cinnamate, n-propyl cinnamate and benzyl cinnamate) had m/z 131 with higher abundance. By analyzing the structure of compound ethyl cinnamate, n-propyl cinnamate and benzyl cinnamate, these similar fragments were due to consecutive losses of the cinnamoyl moiety (m/z 131). The mechanisms show the common fragmentation behavior of the cinnamic esters.The fragmentation mechanism of mass spectra of these β-agonists show that dehydration reactions occurred in the pathways of each compound. A common characteristic was observed that there was neutral loss of a water molecule for all β-agonists. And for 7 β-agonists, loss of an alkyl group from the secondary amine was demonstrated. Moreover, m/z at 74 and 60 were for the butyl and propyl derivatives respectively.

The fragmentation pathway of crocin, crocetin and geniposide were studied. The DP and CE values of crocin were higher than those of crocetin which may be because of the stable gentiobiosyl bond and large molecular weight of crocin. The precursor ion [M-H]− (m/z 975) of crocin had potential to loss gentiobiosyl (m/z 324) for [M-H-gen]− (m/z 651) and to loss 2 gentiobiosyl (m/z 648) for crocetin (m/z 327).

 

Biography:

Abstract:

Hydrothermal liquefaction (HTL) is a promising technology for producing high density liquid fuels from kenaf, a herbaceous biomass. Also, high density liquid fuels through HTL can be used to conbustion fuels as heavy oil in power plant. HTL was used to process Korean native kenaf as energy crops to produce bio crude oil, bio char, gas and aquous phase products. In this study, in order to determine the optimal condition of HTL process, the kenaf was treated using 1-7% (w/w) NaOH at 250-350 °C for 120 min. Subsequently, the mixed products (bio crude oil, bio char, and aqueous phase) were extracted by dichloromethan to only obtain bio crude oil. As a results, bio crude oil yield was approximately 20 % and bio char was produced approximately 10%. And, gas phase was mainly composed carbon dioxide and methane. After HTL process, kenaf convert to liquid fuels as conbustion fuels with high density, high calroie value, and high carbon content. The HTL process are effective procedures to produce the high quality bio crude oil.

 

Biography:

Abstract:

The aim of the present study was to investigate the effect of extraction conditions on the molecular structure of alkaline and organosolv lignins extracted from Korea native herbaceous(Miscanthus and Kenaf). The lignin fractions obtained were then characterized by EA, ICP-AES, TGA, GPC, FT-IR, NMR, Py-GC/MS, and sugar analysis. The structural characterization of lignin will be improving the understanding of complex lignocellulosic biomass pretreatment which is vital for the production of biofuels and phenolic compounds. Comparing the two pretreatment methods, it was found that Mn, Mw and polydispersity of the lignin extracted with ethanol solutions was lower than lignin extracted with alkaline solutions. Elemental composition of Lignins increased in carbon content, and the oxygen content, as expected, decreased.  FTIR analysis of pretreated solid residues revealed reduction in p-hydroxyphenyl (H), guaiacyl (G) and syringyl (S) lignin, FTIR and p-NMR of these lignins showed S, H and G units. The lignin’s physical and chemical behavior was seen different with respect to the extraction method used.

 

Speaker
Biography:

Abstract:

The pH-sensitive films were developed using starch/gelatin loaded with red radish anthocyanin for meat spoilage observation. This work combined several benefits which can possibly utilize in food samples, including bio-compatible material and natural dye based, low cost, fast response, and ease of use. The colors of films could be differentiated by naked eye changing from orange to grey-purple at pH 2-12 and captured by smartphone in the studio light box. The color parameters were evaluated by image J software. To confirm that red radish anthocyanin could incoporate to polymers, films were characterized by FTIR, SEM and AFM. Regarding the color stability trial, the results showed the preferable storage temperature of films was refrigeration temperature. Furthermore, the pH-sensitive films were applied to food samples for real-time meat spoilage observation, the results suggested that films could be used as intelligent food packaging.