Green Chemistry and Technology

Biography

Biography: Dina A. Ahmed

Abstract

Acquisition of the dissolution profiles of more than single active ingredient in a multi-component pharmaceutical formulation is dominated by utilization of the off-line spectroscopic and chromatographic methods. In this approach, a “Double-Dip” green analytical chemistry (GAC) approach with the ultimate goal of advancing the in-line potentiometric sensors to their most effective use for simultaneous acquisition of the dissolution curves of two active ingredients in a binary pharmaceutical dosage form, Brufen Flu is adopted. For the proof of concept, two sensitive and selective sensors were developed for the simultaneous determination of the cationic Pseudoephedrine (PSE) and the anionic Ibuprofen (IBU) drugs in order to monitor their dissolution profiles without sample pretreatment or derivatization. For the determination of the cationic drug (PSE), sensor I was developed using potassium tetrakis (4-chlorophenyl)borate (KTCPB) as a cationic exchanger, while sensor II was developed for the determination of the anionic IBU using tridodecyl methyl ammonium chloride (TDC) as an anionic exchanger using 2-nitrophenyl octyl ether (2-NPOE) as a plasticizer for both used sensors. The use of these novel sensors not only provides a way for the determination of PSE and IBU in bulk powder, in laboratory mixtures and in combined dosage form but also permits simultaneous in-line monitoring of their dissolution profiles. The advantages of the newly introduced “Double-Dip” approach are highlighted and the merits of these benign real-time analyzers (ISEs) that can deliver equivalent analytical results as HPLC and UV-spectrophotometry while significantly reducing solvent consumption/waste generation in addition to the manipulation steps are described.