Zhiyong Hu
Ruhr-Universität Bochum, Germany
Title: Carboxylate-Directed C–H Allylation with Allyl Alcohols or Ethers
Biography
Biography: Zhiyong Hu
Abstract
A [Ru(p-cymene)Cl2]2 catalyst activates allyl alcohols and ethers for the regioselective ortho-C–H allylation of aromatic and heteroaromatic carboxylates. The reaction is orthogonal to most C–H functionalizations with allyl alcohols in that allyl arenes rather than carbonyl compounds are obtained. A wide range of substrates are thus smoothly transformed to allylarenes at 50 °C in phosphate-buffered 2,2,2-trichloroethanol. The reaction concept combines the use of abundant reagents and directing groups in a sustainable, waste-minimized method for C–C bond formation.