Carla Gomes
University of Coimbra, Portugal
Title: Mechanochemistry for two-step synthesis of porphyrins
Biography
Biography: Carla Gomes
Abstract
The remarkable versatility of porphyrins and their derivatives, clearly demonstrated by the large number of applications, relies in a great length on the development and improvement of synthetic strategies that, over the years, made possible the huge availability of these compounds. The synthesis of meso-substituted porphyrins from pyrrole and aldehyde involves the cyclization to obtain the porphyrinogen and the oxidation to aromatize it to porphyrin. With the awakening for the environmental issues and the establishment of Green Chemistry began the search for new synthetic methodologies often using new tools such as microwave or mechanochemistry. In this communication we report the synthesis of porphyrins using mechanochemistry. The influence of the ball milling process in the cyclization and oxidation step, the acid catalyst, the oxidant, the substitution at the aldehyde and the presence and type of solvent will be discussed.
